Science
BeDaddy® a été développé en s’appuyant sur des études scientifiques menées sur le rôle du stress oxydatif, de la génétique, de l’alimentation et des facteurs environnementaux sur la qualité spermatique.
1.1 Les causes de l’infertilité masculine
Le stress oxydatif
Le stress oxydatif est l’une des principales causes d’infertilité idiopathique masculine : il est associé avec un risque accru de fragmentation de l’ADN spermatique, une diminution de la motilité des spermatozoïdes, une concentration et une morphologie anormales.
L’alimentation
Plusieurs études cliniques montrent qu’une alimentation inappropriée, le surpoids et l’obésité sont des facteurs négatifs responsables d’une altération de la qualité spermatique.
Les facteurs environnementaux
Plusieurs facteurs environnementaux et de style de vie – les habitudes alimentaires, l’activité physique, le poids, la consommation de tabac, de drogue et d’alcool – auraient une influence sur le stress oxydatif et, par voie de conséquence, sur les paramètres spermatiques et sur la fertilité masculine. À l’inverse, un changement d’habitudes alimentaires est susceptible d’améliorer la qualité spermatique.
L’intérêt des compléments alimentaires
Une revue de 2018 prenant en compte des études cliniques publiées entre 2002 et 2017 montre l’intérêt de l’utilisation d’antioxydants oraux comme les vitamines C et E, la carnitine, le CoQ10, le zinc, ou le sélénium sur la qualité spermatique d’hommes hypofertiles.
1.2 Le rôle de la génétique
En adhérant au programme BeDaddy, votre médecin va vous prescrire un génotypage. C’est à partir de ce dernier et de votre phénotype que votre Nutrinome® va être calculé.
Les gènes analysés ont été sélectionnés pour leur implication dans le métabolisme et parce que certaines mutations sur ces gènes entraînent des désordres métaboliques et auraient ainsi des effets indirects sur votre fertilité.
19 gènes ont été sélectionnés sur la base de résultats scientifiques montrant qu’il était possible d’agir sur ces désordres métaboliques via à une nutrition adaptée.
- 5 gènes régulant l’équilibre RedOx
- 5 gènes régulant le métabolisme énergétique
- 4 gènes régulant le métabolisme des acides aminés et des vitamines
- 2 gènes régulant la qualité de vie
- 3 gènes régulant le métabolisme lipidique
Pour chacun de ces gènes et en fonction de la mutation identifiée, notre algorithme Salus® optimisera vos besoins en certains nutriments. En pratique, votre alimentation sera totalement individualisée pour vous permettre d’améliorer votre métabolisme et votre fertilité.
Principales références scientifiques
Fertilité / Style de vie & Nutrition
Carlos, S., De La Fuente-Arrillaga, C., Bes-Rastrollo, M., Razquin, C., Rico-Campà, A., Martínez-González, M., & Ruiz-Canela, M. (2018). Mediterranean Diet and Health Outcomes in the SUN Cohort. Nutrients, 10(4), 439.
Chavarro, J. E., & Schlaff, W. D. (2018). Introduction. Fertility and Sterility, 110(4),
557–559.
Chiu, Y.-H., Chavarro, J. E., & Souter, I. (2018). Diet and female fertility: doctor, what should I eat? Fertility and Sterility, 110(4), 560–569.
Chiu, Y.-H., Gaskins, A. J., Williams, P. L., Mendiola, J., Jørgensen, N., Levine, H., … Chavarro, J. E. (2016). Intake of Fruits and Vegetables with Low-to-Moderate Pesticide Residues Is Positively Associated with Semen-Quality Parameters among Young Healthy Men. The Journal of Nutrition, 146(5), 1084–1092.
Danielewicz, A., Przybyłowicz, K., & Przybyłowicz, M. (2018). Dietary Patterns and Poor Semen Quality Risk in Men: A Cross-Sectional Study. Nutrients, 10(9), 1162.
Efrat, M., Stein, A., Pinkas, H., Unger, R., & Birk, R. (2018). Dietary patterns are positively associated with semen quality. Fertility and Sterility, 109(5), 809–816.
Gabrielsen, J. S., & Tanrikut, C. (2016). Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis. Andrology, 4(4), 648–661.
Gaskins, A. J., & Chavarro, J. E. (2017). Diet and fertility: a review. American Journal of Obstetrics and Gynecology.
Gaskins, A. J., & Chavarro, J. E. (2018). Diet and fertility: a review. American Journal of Obstetrics and Gynecology, 218(4), 379–389.
Hayden, R. P., Flannigan, R., & Schlegel, P. N. (2018). The Role of Lifestyle in Male Infertility: Diet, Physical Activity, and Body Habitus. Current Urology Reports, 19(7).
Messerlian, C., Williams, P. L., Ford, J. B., Chavarro, J. E., Mínguez-Alarcón, L., Dadd, R., … for the EARTH Study Team. (2018). The Environment and Reproductive Health (EARTH) Study: a prospective preconception cohort. Human Reproduction Open, 2018(2).
Nassan, F. L., Chavarro, J. E., & Tanrikut, C. (2018). Diet and men’s fertility: does diet affect sperm quality? Fertility and Sterility, 110(4), 570–577.
Orzylowska, E. M., Jacobson, J. D., Bareh, G. M., Ko, E. Y., Corselli, J. U., & Chan, P. J. (2016). Food intake diet and sperm characteristics in a blue zone: a Loma Linda Study. European Journal of Obstetrics & Gynecology and Reproductive Biology, 203, 112–115.
Panth, N., Gavarkovs, A., Tamez, M., & Mattei, J. (2018). The Influence of Diet on Fertility and the Implications for Public Health Nutrition in the United States. Frontiers in Public Health, 6.
Ricci, E., Al-Beitawi, S., Cipriani, S., Alteri, A., Chiaffarino, F., Candiani, M., … Parazzini, F. (2018). Dietary habits and semen parameters: a systematic narrative review. Andrology, 6(1), 104–116.
Salas-Huetos, A., Bulló, M., & Salas-Salvadó, J. (2017). Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Human Reproduction Update, 23(4), 371–389.
Schagdarsurengin, U., & Steger, K. (2016). Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health. Nature Reviews Urology, 13(10), 584–595.
Silva, T., Jesus, M., Cagigal, C., & Silva, C. (2018). Food with influence in the sexual and reproductive health. Current Pharmaceutical Biotechnology, 19.
Skrzypek, M., Wdowiak, A., & Marzec, A. (2017). Application of dietetics in reproductive medicine. Annals of Agricultural and Environmental Medicine.
Fertilité & Stress Oxydatif
Adewoyin, M., Ibrahim, M., Roszaman, R., Isa, M., Alewi, N., Rafa, A., & Anuar, M. (2017). Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress. Diseases, 5(1), 9.
Agarwal, A., & Bui, A. D. (2017). Oxidation-reduction potential as a new marker for oxidative stress: Correlation to male infertility. Investigative and Clinical Urology, 58(6), 385.
Agarwal, A., Roychoudhury, S., Bjugstad, K. B., & Cho, C.-L. (2016). Oxidation-reduction potential of semen: what is its role in the treatment of male infertility? Therapeutic Advances in Urology, 8(5), 302–318.
Ahmadi, S., Bashiri, R., Ghadiri-Anari, A., & Nadjarzadeh, A. (2016). Antioxidant supplements and semen parameters: An evidence based review. International Journal of Reproductive Biomedicine (Yazd, Iran), 14(12), 729–736.
Aitken, R. J. (2016). Oxidative stress and the etiology of male infertility. Journal of Assisted Reproduction and Genetics, 33(12), 1691–1692.
Ajina, T., Sallem, A., Haouas, Z., & Mehdi, M. (2017). Total antioxidant status and lipid peroxidation with and without in vitro zinc supplementation in infertile men. Andrologia, 49(7), e12703.
Alahmar, A. T. (2018). The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia. Clinical and Experimental Reproductive Medicine, 45(2), 57–66.
Alizadeh, F., Javadi, M., Karami, A. A., Gholaminejad, F., Kavianpour, M., & Haghighian, H. K. (2018). Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: A randomized clinical trial. Phytotherapy Research, 32(3), 514–521.
Beigi Harchegani, A., Dahan, H., Tahmasbpour, E., Bakhtiari kaboutaraki, H., & Shahriary, A. (2018). Effects of zinc deficiency on impaired spermatogenesis and male infertility: the role of oxidative stress, inflammation and apoptosis. Human Fertility, 1–12.
Bisht, S., & Dada, R. (2017). Oxidative stress: Major executioner in disease pathology, role in sperm DNA damage and preventive strategies. Frontiers in Bioscience (Scholar Edition), 9, 420–447.
Busetto, G. M., Agarwal, A., Virmani, A., Antonini, G., Ragonesi, G., Del Giudice, F., … De Berardinis, E. (2018). Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: A double-blind placebo-controlled study. Andrologia, 50(3), e12927.
Darbandi, M., Darbandi, S., Agarwal, A., Sengupta, P., Durairajanayagam, D., Henkel, R., & Sadeghi, M. R. (2018). Reactive oxygen species and male reproductive hormones. Reproductive Biology and Endocrinology, 16(1).
Dattilo, M., Giuseppe, D., Ettore, C., & Ménézo, Y. (2016). Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet. Journal of Assisted Reproduction and Genetics, 33(12), 1633–1648.
Dobrakowski, M., Kaletka, Z., Machoń-Grecka, A., Kasperczyk, S., Horak, S., Birkner, E., … Kasperczyk, A. (2018). The Role of Oxidative Stress, Selected Metals, and Parameters of the Immune System in Male Fertility. Oxidative Medicine and Cellular Longevity, 2018, 1–8.
Dorostghoal, M., Kazeminejad, S. R., Shahbazian, N., Pourmehdi, M., & Jabbari, A. (2017). Oxidative stress status and sperm DNA fragmentation in fertile and infertile men. Andrologia, 49(10), e12762.
Eroglu, M., Sahin, S., Durukan, B., Ozakpinar, O. B., Erdinc, N., Turkgeldi, L., … Karateke, A. (2014). Blood serum and seminal plasma selenium, total antioxidant capacity and coenzyme q10 levels in relation to semen parameters in men with idiopathic infertility. Biological Trace Element Research, 159(1–3), 46–51.
Fernandez, M. C., & O’Flaherty, C. (2018). Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa. Human Reproduction, 33(8), 1394–1407.
García Rodríguez, A., de la Casa, M., Johnston, S., Gosálvez, J., & Roy, R. (2018). Association of polymorphisms in genes coding for antioxidant enzymes and human male infertility. Annals of Human Genetics.
Ghiasvand, T., Goodarzi, M. T., Shafiee, G., Zamani, A., Karimi, J., Ghorbani, M., & Amiri, I. (2018). Association between seminal plasma neopterin and oxidative stress in male infertility: A case-control study. International Journal of Reproductive Biomedicine (Yazd, Iran), 16(2), 93–100.
Ilić, B. S., Kolarević, A., Kocić, G., & Šmelcerović, A. (2018). Ascorbic acid as DNase I inhibitor in prevention of male infertility. Biochemical and Biophysical Research Communications, 498(4), 1073–1077.
Kobori, Y., Suzuki, K., Iwahata, T., Shin, T., Sadaoka, Y., Sato, R., … Rohdewald, P. (2015). Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol®. Archivio Italiano Di Urologia e Andrologia, 87(3), 190.
Kumar, N., & Singh, A. K. (2018). Reactive Oxygen Species in Seminal Plasma as a Cause of Male Infertility. Journal of Gynecology Obstetrics and Human Reproduction.
Landfors, M., Nakken, S., Fusser, M., Dahl, J.-A., Klungland, A., & Fedorcsak, P. (2016). Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations. Fertility and Sterility, 105(5), 1170-1179.e5.
Lazzarino, G., Listorti, I., Muzii, L., Amorini, A. M., Longo, S., Di Stasio, E., … Bilotta, P. (2018). Low-molecular weight compounds in human seminal plasma as potential biomarkers of male infertility. Human Reproduction (Oxford, England), 33(10), 1817–1828.
Leisegang, K., Henkel, R., & Agarwal, A. (2017). Redox Regulation of Fertility in Aging Male and the Role of Antioxidants: A Savior or Stressor. Current Pharmaceutical Design, 23(30).
Lipovac, M., Bodner, F., Imhof, M., & Chedraui, P. (2016). Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters. Reproductive Biology and Endocrinology, 14(1).
Magdi, Y., Darwish, E., Elbashir, S., Majzoub, A., & Agarwal, A. (2017). Effect of modifiable lifestyle factors and antioxidant treatment on semen parameters of men with severe oligoasthenoteratozoospermia. Andrologia, 49(7), e12694.
Majzoub, A., & Agarwal, A. (2018). Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate. Arab Journal of Urology, 16(1), 113–124.
Martínez-Soto, J. C., Domingo, J. C., Cordobilla, B., Nicolás, M., Fernández, L., Albero, P., … Landeras, J. (2016). Dietary supplementation with docosahexaenoic acid (DHA) improves seminal antioxidant status and decreases sperm DNA fragmentation. Systems Biology in Reproductive Medicine, 62(6), 387–395.
Mayorga-Torres, B. J. M., Camargo, M., Cadavid, á. P., du Plessis, S. S., & Cardona Maya, W. D. (2016). Are oxidative stress markers associated with unexplained male infertility? Andrologia.
O’Flaherty, C., & Matsushita-Fournier, D. (2017). Reactive oxygen species and protein modifications in spermatozoa†. Biology of Reproduction, 97(4), 577–585.
Palmieri, M., Papale, P., Della Ragione, A., Quaranta, G., Russo, G., & Russo, S. (2016). Antioxidant Treatment of Semen Samples in Assisted Reproductive Technology: Effects of Myo-Inositol on Nemaspermic Parameters. International Journal of Endocrinology, 2016, 1–5.
Roychoudhury, S., Agarwal, A., Virk, G., & Cho, C.-L. (2017). Potential role of green tea catechins in the management of oxidative stress-associated infertility. Reproductive BioMedicine Online, 34(5), 487–498.
Sabeti, P., Pourmasumi, S., Rahiminia, T., Akyash, F., & Talebi, A. R. (2016). Etiologies of sperm oxidative stress. International Journal of Reproductive Biomedicine (Yazd, Iran), 14(4), 231–240.
Showell, M. G., Mackenzie-Proctor, R., Brown, J., Yazdani, A., Stankiewicz, M. T., & Hart, R. J. (2014). Antioxidants for male subfertility. Cochrane Database of Systematic Reviews.
Silberstein, T., Har-Vardi, I., Harlev, A., Friger, M., Hamou, B., Barac, T., … Saphier, O. (2016). Antioxidants and Polyphenols: Concentrations and Relation to Male Infertility and Treatment Success. Oxidative Medicine and Cellular Longevity, 2016, 1–5.
Smits, R. M., Mackenzie-Proctor, R., Fleischer, K., & Showell, M. G. (2018). Antioxidants in fertility: impact on male and female reproductive outcomes. Fertility and Sterility, 110(4), 578–580.
Subramanian, V., Ravichandran, A., Thiagarajan, N., Govindarajan, M., Dhandayuthapani, S., & Suresh, S. (2018). Seminal reactive oxygen species and total antioxidant capacity: Correlations with sperm parameters and impact on male infertility. Clinical and Experimental Reproductive Medicine, 45(2), 88.
Tiseo, B. C., Gaskins, A. J., Hauser, R., Chavarro, J. E., & Tanrikut, C. (2017). Coenzyme Q10 Intake From Food and Semen Parameters in a Subfertile Population. Urology, 102, 100–105.
Yao, D., & Mills, J. (2016). Male infertility: lifestyle factors and holistic, complementary, and alternative therapies. Asian Journal of Andrology, 18(3), 410.
Fertilité / Fragmentation de l’ADN Spermatique & Stress Oxydatif
Al Omrani, B., Al Eisa, N., Javed, M., Al Ghedan, M., Al Matrafi, H., & Al Sufyan, H. (2018). Associations of sperm DNA fragmentation with lifestyle factors and semen parameters of Saudi men and its impact on ICSI outcome. Reproductive Biology and Endocrinology: RB&E, 16(1), 49.
Alvarez Sedó, C., Bilinski, M., Lorenzi, D., Uriondo, H., Noblía, F., Longobucco, V., … Nodar, F. (2017). Effect of sperm DNA fragmentation on embryo development: clinical and biological aspects. JBRA Assisted Reproduction, 21(4), 343–350.
Bosco, L., Notari, T., Ruvolo, G., Roccheri, M. C., Martino, C., Chiappetta, R., … Montano, L. (2018). Sperm DNA fragmentation: An early and reliable marker of air pollution. Environmental Toxicology and Pharmacology, 58, 243–249.
Carlini, T., Paoli, D., Pelloni, M., Faja, F., Dal Lago, A., Lombardo, F., … Gandini, L. (2017). Sperm DNA fragmentation in Italian couples with recurrent pregnancy loss. Reproductive BioMedicine Online, 34(1), 58–65.
Cho, C.-L., & Agarwal, A. (2018). Role of sperm DNA fragmentation in male factor infertility: A systematic review. Arab Journal of Urology, 16(1), 21–34.
Colaco, S., & Sakkas, D. (2018). Paternal factors contributing to embryo quality. Journal of Assisted Reproduction and Genetics.
Comar, V. A., Petersen, C. G., Mauri, A. L., Mattila, M., Vagnini, L. D., Renzi, A., … Franco Jr, J. G. (2017). Influence of the abstinence period on human sperm quality: analysis of 2,458 semen samples. JBRA Assisted Reproduction.
Duarte, C., Núñez, V., Wong, Y., Vivar, C., Benites, E., Rodriguez, U., … Ponce, J. (2017). Impact of the Z potential technique on reducing the sperm DNA fragmentation index, fertilization rate and embryo development. JBRA Assisted Reproduction.
Esbert, M., Pacheco, A., Soares, S. R., Amorós, D., Florensa, M., Ballesteros, A., & Meseguer, M. (2018). High sperm DNA fragmentation delays human embryo kinetics when oocytes from young and healthy donors are microinjected. Andrology.
Esteves, S. C. (2018). Testicular versus ejaculated sperm should be used for intracytoplasmic sperm injection (ICSI) in cases of infertility associated with sperm DNA fragmentation | Opinion: Yes. International Braz j Urol, 44(4), 667–675.
Garolla, A., Ghezzi, M., Cosci, I., Sartini, B., Bottacin, A., Engl, B., … Foresta, C. (2017). FSH treatment in infertile males candidate to assisted reproduction improved sperm DNA fragmentation and pregnancy rate. Endocrine, 56(2), 416–425.
Kim, G. Y. (2018). What should be done for men with sperm DNA fragmentation? Clinical and Experimental Reproductive Medicine, 45(3), 101.
Kumar, N., & Singh, A. K. (2018). Reactive Oxygen Species in Seminal Plasma as a Cause of Male Infertility. Journal of Gynecology Obstetrics and Human Reproduction.
Lu, J.-C., Jing, J., Chen, L., Ge, Y.-F., Feng, R.-X., Liang, Y.-J., & Yao, B. (2018). Analysis of human sperm DNA fragmentation index (DFI) related factors: a report of 1010 subfertile men in China. Reproductive Biology and Endocrinology, 16(1).
McSwiggin, H. M., & O’Doherty, A. M. (2018). Epigenetic reprogramming during spermatogenesis and male factor infertility. Reproduction, 156(2), R9–R21.
Oumaima, A., Tesnim, A., Zohra, H., Amira, S., Ines, Z., Sana, C., … Meriem, M. (2018). Investigation on the origin of sperm morphological defects: oxidative attacks, chromatin immaturity, and DNA fragmentation. Environmental Science and Pollution Research.
Panner Selvam, M. K., & Agarwal, A. (2018). A systematic review on sperm DNA fragmentation in male factor infertility: Laboratory assessment. Arab Journal of Urology, 16(1), 65–76.
Roque, M., & Esteves, S. C. (2018). Effect of varicocele repair on sperm DNA fragmentation: a review. International Urology and Nephrology, 50(4), 583–603.
Sigman, M. (2018). Testicular versus ejaculated sperm should be used for intracytoplasmic sperm injection (ICSI) in cases of infertility associated with sperm DNA fragmentation | Opinion: No. International Braz j Urol, 44(4), 676–679.
Simon, L., Emery, B. R., & Carrell, D. T. (2017). Review: Diagnosis and impact of sperm DNA alterations in assisted reproduction. Best Practice & Research Clinical Obstetrics & Gynaecology, 44, 38–56.
Stenqvist, A., Oleszczuk, K., Leijonhufvud, I., & Giwercman, A. (2018). Impact of antioxidant treatment on DNA fragmentation index: a double-blind placebo-controlled randomized trial. Andrology.
Wiweko, B., & Utami, P. (2017). Predictive value of sperm deoxyribonucleic acid (DNA) fragmentation index in male infertility. Basic and Clinical Andrology, 27(1).
Zandieh, Z., Vatannejad, A., Doosti, M., Zabihzadeh, S., Haddadi, M., Bajelan, L., … Amanpour, S. (2018). Comparing reactive oxygen species and DNA fragmentation in semen samples of unexplained infertile and healthy fertile men. Irish Journal of Medical Science (1971 -), 187(3), 657–662.
Zeqiraj, A., Beadini, S., Beadini, N., Aliu, H., Gashi, Z., Elezaj, S., … Shabani, A. (2018). Male Infertility and Sperm DNA Fragmentation. Open Access Macedonian Journal of Medical Sciences, 6(8), 1342–1345.
Fertilité et environnement
Aboulmaouahib, S., Madkour, A., Kaarouch, I., Sefrioui, O., Saadani, B., Copin, H., … Cadi, R. (2018). Impact of alcohol and cigarette smoking consumption in male fertility potential: Looks at lipid peroxidation, enzymatic antioxidant activities and sperm DNA damage. Andrologia, 50(3), e12926.
Antoniassi, M. P., Intasqui, P., Camargo, M., Zylbersztejn, D. S., Carvalho, V. M., Cardozo, K. H. M., & Bertolla, R. P. (2016). Analysis of the functional aspects and seminal plasma proteomic profile of sperm from smokers. BJU International, 118(5), 814–822.
Asare-Anane, H., Bannison, S. B., Ofori, E. K., Ateko, R. O., Bawah, A. T., Amanquah, S. D., … Ziem, J. B. (2016). Tobacco smoking is associated with decreased semen quality. Reproductive Health, 13(1).
Barbonetti, A., Castellini, C., Di Giammarco, N., Santilli, G., Francavilla, S., & Francavilla, F. (2016). In vitro exposure of human spermatozoa to bisphenol A induces pro-oxidative/apoptotic mitochondrial dysfunction. Reproductive Toxicology, 66, 61–67.
Bergamo, P., Volpe, M. G., Lorenzetti, S., Mantovani, A., Notari, T., Cocca, E., … Montano, L. (2016). Human semen as an early, sensitive biomarker of highly polluted living environment in healthy men: A pilot biomonitoring study on trace elements in blood and semen and their relationship with sperm quality and RedOx status. Reproductive Toxicology (Elmsford, N.Y.), 66, 1–9.
Borges, E., Braga, D. P. de A. F., Provenza, R. R., Figueira, R. de C. S., Iaconelli, A., & Setti, A. S. (2018). Paternal lifestyle factors in relation to semen quality and in vitro reproductive outcomes. Andrologia, e13090.
Chen, Q., Yang, H., Zhou, N., Sun, L., Bao, H., Tan, L., … Cao, J. (2017). Phthalate exposure, even below US EPA reference doses, was associated with semen quality and reproductive hormones: Prospective MARHCS study in general population. Environment International, 104, 58–68.
Chianese, R., Troisi, J., Richards, S., Scafuro, M., Fasano, S., Guida, M., … Meccariello, R. (2017). Bisphenol A in reproduction: epigenetic effects. Current Medicinal Chemistry, 24.
Comhaire, F. H., Vandenberghe, W., & Decleer, W. (2017). External factors affecting fertility, and how to correct their impact. Facts, Views & Vision in ObGyn, 9(4), 217–221.
Condorelli, R. A., La Vignera, S., Giacone, F., Iacoviello, L., Mongioì, L. M., Li Volti, G., … Calogero, A. E. (2017). Nicotine Effects and Receptor Expression on Human Spermatozoa: Possible Neuroendocrine Mechanism. Frontiers in Physiology, 8.
Consales, C., Toft, G., Leter, G., Bonde, J. P. E., Uccelli, R., Pacchierotti, F., … Spanò, M. (2016). Exposure to persistent organic pollutants and sperm DNA methylation changes in Arctic and European populations. Environmental and Molecular Mutagenesis, 57(3), 200–209.
Cremonese, C., Piccoli, C., Pasqualotto, F., Clapauch, R., Koifman, R. J., Koifman, S., & Freire, C. (2017). Occupational exposure to pesticides, reproductive hormone levels and sperm quality in young Brazilian men. Reproductive Toxicology (Elmsford, N.Y.), 67, 174–185.
Esakky, P., & Moley, K. H. (2016). Paternal smoking and germ cell death: A mechanistic link to the effects of cigarette smoke on spermatogenesis and possible long-term sequelae in offspring. Molecular and Cellular Endocrinology, 435, 85–93.
Gabrielsen, J. S., & Tanrikut, C. (2016). Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis. Andrology, 4(4), 648–661.
Giudice, L. C. (2016). Environmental toxicants: hidden players on the reproductive stage. Fertility and Sterility, 106(4), 791–794.
Goldstone, A. E., Chen, Z., Perry, M. J., Kannan, K., & Louis, G. M. B. (2015). Urinary bisphenol A and semen quality, the LIFE Study. Reproductive Toxicology (Elmsford, N.Y.), 51, 7–13.
Habas, K., Najafzadeh, M., Baumgartner, A., Brinkworth, M. H., & Anderson, D. (2017). An evaluation of DNA damage in human lymphocytes and sperm exposed to methyl methanesulfonate involving the regulation pathways associated with apoptosis. Chemosphere, 185, 709–716.
Hanson, H. A., Mayer, E. N., Anderson, R. E., Aston, K. I., Carrell, D. T., Berger, J., … Hotaling, J. M. (2016). Risk of childhood mortality in family members of men with poor semen quality. Human Reproduction.
Jurewicz, J., Radwan, M., Wielgomas, B., Dziewirska, E., Karwacka, A., Klimowska, A., … Hanke, W. (2017). Human Semen Quality, Sperm DNA Damage, and the Level of Reproductive Hormones in Relation to Urinary Concentrations of Parabens. Journal of Occupational and Environmental Medicine, 59(11), 1034–1040.
Jurewicz, J., Radwan, M., Wielgomas, B., Kałużny, P., Klimowska, A., Radwan, P., & Hanke, W. (2018). Environmental levels of triclosan and male fertility. Environmental Science and Pollution Research, 25(6), 5484–5490.
Lalinde-Acevedo, P., Torres, B. J. M., Agarwal, A., Plessis, S. du, Ahmad, G., Cadavid, A., & Maya, W. C. (2017). Physically Active Men Show Better Semen Parameters than Their Sedentary Counterparts. Int J Fertil Steril, (3).
Mínguez-Alarcón, L., Hauser, R., & Gaskins, A. J. (2016). Effects of bisphenol A on male and couple reproductive health: a review. Fertility and Sterility, 106(4), 864–870.
Mohamad Al-Ali, B., & Eredics, K. (2017). Synergistic effects of cigarette smoking and varicocele on semen parameters in 715 patients. Wiener Klinische Wochenschrift, 129(13–14), 482–486.
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